Microbicides Toolkit

Microbicides are topical agents that are being tested to help prevent the sexual transmission of HIV. Vaginal microbicides are intended as an HIV prevention option for women, especially those who may have trouble negotiating condom use with their sexual partners. Rectal microbicides, which could be used by both men and women to reduce the risk of HIV infection during anal sex, are also being developed.

The most widely studied microbicides have been formulated as gels that are used either daily or before and after sex. However, other microbicide products, such as vaginal rings, can release an active drug over time. Most of the microbicides under study employ antiretroviral drugs that are commonly used in pill form to treat an HIV infection.

Antiretroviral pill formulations are also being studied for HIV prevention in an approach called pre-exposure prophylaxis (PrEP). On July 16, 2012, the U.S. Food and Drug Administration approved the use of a combination of the antiretroviral drugs tenofovir disoproxil fumarate and emtricitabine (TDF/FTC, or Truvada) for daily use as PrEP to reduce the risk of HIV infection in uninfected men and women who are at high risk of HIV infection and who may engage in sexual activity with HIV-infected partners.

This toolkit provides information about microbicides for health policymakers, program managers, community educators, trainers, advocates and communication specialists. Although microbicides are not yet available, this toolkit can help the reader develop implementation strategies once they come to the marketplace. This toolkit will be updated continually as the field progresses.

The introduction of microbicides will require a comprehensive approach, including:
  • Knowledge of recent research results
  • Up-to-date policies and guidelines
  • Effective communication and marketing
  • Quality training, supervision, and services
  • Proper logistics

The thematic navigation tabs (listed above) provide the basic information, tools, and resources you will need to understand and introduce microbicides once they become available.

Are there new resources or topic areas that should be included in this toolkit? Share your suggestions, comments, and questions through the feedback form.
 
To find out whether a resource has already been included in this toolkit, visit the site map or type the title in the search box. Visit the About page for more detailed information about the selection of resources, a list of publishers, and other K4Health toolkits.
 
Topics: 
Toolkit last updated: March 07, 2014