The HIV-infection rate in Southern Africa is among the highest in the world. Despite the availability of information on the AIDS pandemic, people are still not changing their behaviour. This study grappled with the question of the role of culture in the spread of HIV/AIDS. UNESCO/UNAIDS observe that there are many different ways of contracting HIV, many different ways of preventing HIV/AIDS, many different groups of people exposed to HIV/AIDS, and many different ways of discriminating against people living with HIV/AIDS. The `whys’, `hows’ and `whos’ change from culture to culture. That is why a culturally-appropriate response to HIV/AIDS prevention and care is needed.